I also imagine that in the ancient past, when we did not have the protection of modern civilization, we were in bigger danger of a negative interaction with spiders, particularly in warm tropical climates. I found this excellent article on prehistoric spiders.
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Definitely, the lack of knowledge on basic hygiene and how to treat and keep wounds clean has helped us survive so much that would have killed our ancestors.
And that spider article is awesome! I haven't heard of this development, but it's amazing. I always figured orb-weavers were the oldest of the true spiders, but it seems the net-casters beat them in this case. hanks to linking it!