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Fair enough - it's worth it anyway for my primary access to getting alts, but most aren't compatible with most hardware wallets just yet to need to sit on the exchange (not best practice). One other point is that you can't use USD or fiat on Bittrex. Gemini has a $500 USD deposit per business day that resets at 5 PM. This is a pre-credited amount you can instantly purchase coins with, BUT you can't withdraw $500 USD worth out of your account until the transaction fully clears between your bank and Gemini (about 4-5 business days). This is an important note to remember for new users looking to buy BTC/ETH to transfer out to buy alts with because your funds will be stuck. You can also wire in larger amounts via your bank if you need. Coinbase is unique as it allows for credit card charges to fund your account, but they usually have pretty small limits for new account holders.

For some reasons I erroneously thought USD was on Bittrex. It was USDT. Then I might understand the caution on these kind of exchange which don't have fiat currencies thus possibly less regulation.

What you think is the best then Bittrex, please suggest a good one..

Depends on what you're looking to buy and where you live in the world. If you could elaborate, I can help.

Bittrex is okay to transact altcoin. It is one of the best exchanges for altcoins. It has a high volume and a pretty good reputation.

Bittrex don't pay your generated gas if you are holding NEO. Binance does. https://www.binance.com/