Apparently there is also cardio vascular disease to be added on top of radiation caused damage, muscle and bone deterioration, renal problems, etc..
Imagine in what shape astronauts would reach Mars:
http://arstechnica.com/science/2016/07/apollo-astronauts-dying-of-heart-disease-at-4-5x-the-rate-of-counterparts/?comments=1
Omg that's not great for astronauts...Dang