Thousands of fighters and their family members will leave the enclave in Hama and Homs city in the country's northern rebel-controlled area, according to the BBC.
According to an agreement with the Syrian President Bashar al-Assad's supporters, these rebel fighters have been given the opportunity to move safely.
The rebels were forced to release the control of the enclosure in front of the operation of the army after long time being blocked. The strategically important city is located in the enclave in the enclave.
After a long discussion from the leader of the Free Syrian Army and the Russian General of the Anti-Assad Armed Forces, on Wednesday, the rebels agreed to leave the area, as a condition that they were given the opportunity to safely move to the north-east of Idlib.
In exchange, the military police promised to protect the bus carrying the rebels and to protect the Shia Alaouit from the vicinity of the civilian Sunni neighborhood, the military's military police said.
Although heavy weapons were submitted, rebel fighters were allowed to carry light arms while traveling to Idlib.
Local residents said before the deal was agreed, Russian aircrafts bombed the enclaves occupying the rebels.
"After the bombing of the civilians, they (the Russian army) did not have any alternative in the hands of rebels. They give the opportunity to choose between the rebels' surrender or the destruction of the civilians, "he told Reuters news agency, Aziz al-Baraji, one of the intermediaries of the rebels.
It is believed that the rebels may take up to two days to leave the enclave.
The BBC said the enclaves would leave the rebels' last big role in establishing the control of government forces on an important highway. The highway, known as M. Fiv, connects Aleppo and Damascus with Homs.
Russia and Iran-assisted Assad Bahini advanced a lot in the seven years of civil war under the control of the enclave. Only some parts of the north and the south of Syria are now under the control of the rebels.
Observers believe that the rebels would have to be attentive to Eidlib in their control. Thousands of warriors and their family members who had left East Gauta had reached the strongest base of anti-Assad elements last month.